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The American Journal of Pathology - ajp.amjpathol.org 923 Accepted Manuscript
Association of KIR genes and their HLA ligands 6-diazo-5-oxo-L-nor-Leucine with colorectal cancers in Lur population of Iran
Bahareh Shayanrad, Koroush Ghanadi, Ali-mohammad Varzi, Mehdi Birjandi, Seyyed Amir Yasin Ahmadi, Farhad Shahsavar
Please cite this article as: B. Shayanrad, K. Ghanadi, A.-m. Varzi, et al., Association of KIR genes and their HLA ligands diversity with colorectal cancers in Lur population of Iran, Meta Gene, https://doi.org/10.1016/j.mgene.2019.100603
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Association of KIR genes and their HLA ligands Diversity with Colorectal Cancers in
Lur Population of Iran
Bahareh Shayanrad1, 2, Koroush Ghanadi3, Ali-mohammad Varzi2, Mehdi Birjandi4, Seyyed Amir Yasin Ahmadi5, 6, Farhad Shahsavar2*
1 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Division of Gastroenterology, Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
4 Department of Epidemiology and Biostatistics, Lorestan University of Medical Sciences, Khorramabad, Iran
5 Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
6 Scientific Society of Evidence-Based Knowledge, Research Office for the History of Persian Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
* Corresponding author: Farhad Shahsavar, [email protected]
Objectives: This study was aimed to evaluate the disease association of each killer-cell immunoglobulin-like receptor (KIR) gene and their known human leukocyte antigen (HLA) ligands (HLA-C and -Bw4) as well as KIR haplotypes and KIR-HLA interactions in Lur population of west of Iran.
Methods: In this case-control study, 50 cases with colorectal cancer and 100 healthy controls were taken. The genomic DNA was extracted and polymerase chain reaction with sequence specific primers (PCR-SSP) was used to genotyping the samples. Statistical analysis was done using 2 by 2 tables. In order to compare the results with other previous studies, funnel plot and cluster analysis was used.
Results: Among the single gene analyses, only the association of KIR2DS5 was statistically significant (Pearson chi-square P =0.0206; Yate's corrected chi-square P =0.0323; OR =2.25 [1.12-4.49 95% CI]). No significant association was observed for neither KIR nor HLA genotypes. Among the KIR-HLA interactions, no significant association was observed as well.
Conclusion: The results of this paper supported the results of previous studies as well as the rationale existing behind the tumor biology. The ligand of KIR2DS5 should be discovered and evaluated in future.
Keywords: KIR, HLA, colorectal cancer