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  • br In the present study

    2020-08-12


    In the present study, salivary ET-1 levels were highly expressed in patients with OSCC, SMF and OL as compared to normal healthy controls. Also, the salivary levels of ET-1 were highly expressed in initial clinical stages of OSCC, implicating the role of ET-1 as a growth factor and tumour initiation factor. It was found that the levels of ET-1 were highly expressed in all stages of SMF, which may indicate its role in oral SCH772984 proliferation and disease progression. Therefore, our results demonstrate potential utility of salivary analysis for ET-1 levels to monitor patients at risk for OSCC.
    This study provides the basis for a larger prospective study to determine the critical levels of salivary ET-1 necessary to diagnose and monitor OPMD’s and its potential to undergo malignant transformation. More research in the direction of including other oral potentially malignant disorders will help us to estimate the levels of salivary ET-1, thereby reducing the incidence of OPMDs and consequently preventing oral carcinogenesis.
    Disclosure of interest
    The authors declare that they have no competing interest.
    References
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    Please cite this article in press as: Ankita K, et al. Assessment of salivary endothelin-1 in patients with leukoplakia, submucous fibrosis, oral cancer and healthy individuals – a comparative study. J Stomatol Oral Maxillofac Surg (2019), https://doi.org/10.1016/ j.jormas.2019.02.024
    [15] Mankapure PK, Barpande SR, Bhavthankar JD, Mandale M, Salehi M. Serum big endothelin-1 as a biomarker in oral squamous cell carcinoma patients: an analytical study. J Appl Oral Sci 2015;23(5):491–6.
    [16] Lam HC, Lo GH, Lee JK, Lu CC, Chu CH, Sun CC, Chuang MJ, Wang MC. Salivary immunoreactive endothelin in patients with upper gastrointestinal diseases. J Cardiovasc Pharmacol 2004;S413–7.
    [17] Ansai T, Yamamoto E, Awano S, Weixian YU, Turner AJ, Takehara T. Effects of periodontopathic bacteria on the expression of endothelin-1 in gingival epithelial cells in adult periodontitis. Proceedings of the seventh international conference on endothelin. Clinical Science 2002;103:327–31.
    [20] Hinsley EE, Hunt S, Hunter KD, Whawell SA, Lambert DW. Endothelin-1 stimulates motility of head and neck squamous carcinoma cells by promoting stromal–epithelial interactions. International journal of cancer. 2012;130(1): 40-7.
    Please cite this article in press as: Ankita K, et al. Assessment of salivary endothelin-1 in patients with leukoplakia, submucous fibrosis, oral cancer and healthy individuals – a comparative study. J Stomatol Oral Maxillofac Surg (2019), https://doi.org/10.1016/ j.jormas.2019.02.024 Clinical Biomechanics 69 (2019) 28–33
    Contents lists available at ScienceDirect
    Clinical Biomechanics
    journal homepage: www.elsevier.com/locate/clinbiomech
    Assessment of the Mini-Balance Evaluation Systems Test, Timed Up and Go T test, and body sway test between cancer survivors and healthy participants
    Shinichiro Morishitaa, , Ryo Hirabayashia, Atsuhiro Tsubakia, Osamu Aokib, Jack B. Fuc, Hideaki Onishia, Tetsuya Tsujid
    a Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Shimami-cho 1398, Kita-ku, Niigata City 950-3198, Japan
    b Faculty of Rehabilitation, Shijonawate Gakuen University, Osaka 574-0011, Japan
    c Department of Palliative, Rehabilitation and Integrative Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    d Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan
    Keywords:
    Muscle strength
    Body sway
    Cancer survivor
    Balance
    Mini-Balance Evaluation Systems Test
    Timed Up and Go 
    Background: Cancer survivors experience late and long-term effects of treatment; also, the disease itself might be responsible for persisting functional impairments. The purpose of this study was to investigate muscle strength, balance function using the Mini-Balance Evaluation Systems Test and Timed Up and Go test with single and cognitive dual tasks and body sway in breast cancer survivors and healthy women and non-breast cancer sur-vivors and healthy participants.