• Prostaglandin J2 br The statistical analysis was

  2022-04-26

  

  The statistical analysis was carried out by using SPSS statistics 22.0 software (IBM Corporation, Armonk, NY, USA). Data are presented as the mean ± SEM. For electrophysiological experiments, statistical comparisons were made by unpaired or one-sample Student's t-test. For cell migration, the diffe

• br Differential metabolites characterization and metabolic

  2022-04-26

  

  2.6. Differential metabolites characterization and metabolic pathway analysis OPLS-DA, a supervised multivariate statistical model, was applied to visualize the metabolic difference between control group and different fraction-treated groups. In the OPLS-DA model, vari-ables with Variable Impor

• br Microarray Gene Expression Profiling br

  2022-04-25

  

  Microarray Gene Expression Profiling The gene expression was obtained in extreme desmoplastic CAFs (four HDEX-CAFs and four LDEX-CAFs; one HDEX-CAF went to senescence and was excluded from gene expression analysis). Early passage (passage 2) cultures of the 7 CAFs were embedded in collagen gel

• br Acknowledgements br This work

  2022-04-22

  

  Acknowledgements This work was supported by the Natural Science Foundation of Shandong Province (ZR2016HB05 and ZR2016HB45), the open project of Shandong Collaborative Innovation Center for Antibody Drugs (CIC-AD1827), the Postdoctoral Science Foundation of China (2018M632607), and the National

• F Spill D S Reynolds R

  2022-04-22

  

  [39] F. Spill, D.S. Reynolds, R.D. Kamm, M.H. Zaman, Impact of the physical micro-environment on tumor progression and metastasis, Curr. Opin. Biotechnol. 40 (2016) 41–48. Contents lists available at ScienceDirect Gene journal homepage: www.elsevier.com/locate/gene Research paper CDCA

• br CDDP drug release experiments from both PEGylated nanogels

  2022-04-21

  

  CDDP drug release experiments from both PEGylated nanogels were carried out in vitro. The percentage of CDDP released from the CCN1 and ACN1 under different conditions are shown in Fig. 2c and d, re-spectively. In a phosphate buffer saline (PBS) solution at pH 7.4, the free CDDP drug diffuses continu

• br of these CRC cells promoted by

  2022-04-20

  

  of these CRC ATPγS promoted by CPA4 was reversed after treatment with cryptotanshinone or U0126 (Fig. 6B–F). The above results may show that CPA4 plays a role in promoting proliferation and inhibiting apopto-sis of CRC by activating the STAT3 and ERK pathways. 4. Discussion In the present s

• ref br cMET cellular Mesenchymal Epithelial Transition facto

  2022-04-16

  

  ref. cMET: cellular Mesenchymal Epithelial Transition factor, ALK: Anaplastic Lymphoma Kinase, LCLC: Large-Cell Lung Cancer, NOS: Not Otherwise Specified, HR: Hazard Ratio, Ref: Reference, CI: Confidence Interval. 4. Discussion The role of c-MET protein overexpression as a prognostic and

• br The above data support Bruceine D

  2022-04-16

  

  The above data support Bruceine D as being a potential candidate to treat cancer. In the present study, we investigate the cytotoxic effects of BD on NSCLC cell lines in vitro and explore the underlying mechanism of BD in cytotoxicity and apoptosis. 2. Materials and methods 2.1. Chemicals and

• br R Jend elovsk et al br where

  2022-04-16

  

  R. Jendželovský et al. where other ABC transporters like MDR1, MRP2 and BCRP were also expressed. Therefore, in the present study, the kinetics of HY in-corporation into the particular cells overexpressing ABC transporters was measured after 2, 4, 8, 12, 16, 24 and 48 h of incubation of cells w

• br Although potential applications of metabolomics findings

  2022-04-15

  

  Although potential applications of metabolomics findings until now are encouraging and their significance is doubtless, limited work has focused on targeted plasma metabolic profiling of BC for accurate di-agnosis and pathogenesis clarification. Few metabolomics studies of BC biomarker discovery h

• br Exosomes are membrane enclosed small vesicles nm with end

  2021-03-03

  

  Exosomes are membrane-enclosed small vesicles (30–100 nm) with endosomal origin that contain numerous molecular components including proteins, mRNAs, as well as miRNAs.35 Exosomes secreted by PSB 1115 play a crucial role in correlating cells and transmit-ting information among tissues over long di

• br Trastuzumab has radically changed the clinical scenario i

  2021-03-03

  

  Trastuzumab has radically changed the clinical scenario in the adjuvant treatment of eBC (leading to a durable 40% reduction of the relative risk of recurrence and to 34% fewer death).6,7 It is noteworthy that no clinical or preclinical evidences support the 12-months duration whose choice was bas

• b iframe width height src https www youtube com embed

  2021-03-03

  

  r> 2.3. Culture of human primary pancreatic ductal epithelial Heparin and murine organoids 2.3.1. Human primary pancreatic cells epithelial cells (HPPE) Human primary pancreatic cells epithelial cells (HPPE) were pur-chased from Cell Biologics, Inc. (Chicago, IL) and grown in T25 tissue cultu

• br ADL score br PCS score

  2021-03-02

  

  ADL score PCS score MCS score Abbreviations: ADL, activities of daily living; IQR, interquartile range; MCS, mental component summary; PCS, physical component sum-mary; SD, standard deviation. * P values for continuous and categorical variables are from the Wilcoxon rank sum test and c

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