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br Table br Percentage of
2020-08-12
Table 1 Percentage of SRS 16-86 arrest induced by fucoidan in HepG2 cancer cells. Concentration (μg/ml) Cell cycle arrest (%) The values are presented as mean ± SD in triplicate and significance (p ≤ 0.05) determined by student t-test between fucoidan treated vs. untreated control.
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br Western blot analysis br
2020-08-12
2.5. Western blot analysis Cells were harvested by trypsinization and pellets were lysed using radioimmunoprecipitation assay (RIPA) buffer (Pierce, USA). Then, the protein concentration was determined by Bio-Rad Bradford Protein assay (Bio-Rad, USA). A hundred micrograms of protein were loaded
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br micelles and MP PPPD micelles
2020-08-12
micelles and MP/PPPD micelles). Two weeks later, tumors were col-lected and evaluated. 2.6. Immunohistochemical staining of Ki-67 and CD31 Evaluation of proliferation of colon tumor were performed by im-munohistochemical staining of Ki-67. In brief, tumor samples were collected and embedded
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Eltanexor br Conclusion br In summary we designed and
2020-08-12
3. Conclusion In summary, we designed and synthesized novel m-carborane-con-taining anti-cancer drug candidates based on the structure of screening-hit compound 1a. Among the synthesized compounds, 3,4,5-tri-methoxybenzyl derivative 2a and 3,4,5-trimethoxybenzoyl derivative 3a showed more poten
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br media used to deliver health information
2020-08-12
media) used to deliver health information fully reflect the target audience’s characteristics, including gender, age, and media preferences. This consideration can help attenuate the audience’s perceived overload of online health information processing and, ultimately, may enhance its health li
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br All enrolled patients were followed
2020-08-12
All enrolled patients were followed up by routine outpatient clinic review and 3 Discussion respectively. Survival curve is shown inMANUSCRIPTFigure1.Therewerenostatisticaldifferences between RCC and LCC groups in the 1-, 3- and 5-year survival rates ( =0.846). However, there were signifi
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br Corresponding author br E mail address Karin
2020-08-12
Corresponding author. E-mail address: [email protected] (K. Chumbimuni-Torres). properties and DNA affinity to these small molecules (Rauf et al., 2005). Unfortunately, these techniques mostly address the issues of structural analysis and binding mechanisms, rather than inves
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br Tumors demonstrating co amplification of multiple
2020-08-12
Tumors demonstrating co-amplification of multiple Ferrostatin 1 were further examined by simultaneous hybridization using two separate probes (labeled with distinct fluorescent markers) against the genes of interest, permitting assessment of the co-existence of the amplified genes or chromosomal
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br Table br Perturbation profiles of mitochondrial complex
2020-08-07
Table 2 Perturbation profiles of mitochondrial complex inhibitors against each complex activity. Compounds MOA Substrates Malate/ Succinate Duroquinol TMPD/ pyruvate ascorbate Rotenone Complex I + − − − Inhibitor Malonate Complex II − + − − Inhibitor An
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br E mail address drelsun com E Sun Kangkang
2020-08-07
E-mail address: [email protected] (E. Sun). 1 Kangkang Liu, Erlin Sun and Mingde Lei contributed equally to this work. (caption on next page) Fig. 1. BCG induced NETs formation. A, a significant morphologic change induced by BCG was shown in neutrophils after a 3-h incubation under an opti
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br Results br A total
2020-08-07
3. Results A total of ten themes for potential barriers and five themes for facil-itators to intervention adherence emerged (see Table 1). The responses indicated factors that inhibit intervention adherence, as well as strate-gies that facilitated participation in the prescribed walking and low
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br aggressiveness Measurement of miR
2020-08-06
aggressiveness.17,18,20,21 Measurement of miR-182 by RT- qPCR in prostate tumor specimens, not microdissected, have found either no significant association21,47 or a positive association of miR-182 expression with recurrence.39 In the study by Casanova-Salas et al,39 medium, but not high level
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br For CD melting procedures AT
2020-08-04
For CD melting procedures, AT11-B0 solutions were prepared in 10 mM KCl and 90 mM LiCl in order to obtain a melting temperature around 50 °C. The denaturation process was analyzed by monitoring the wavelength of maximum ellipticity (260 nm) through temperatures ranging from 10–20 to 110 °C (temper
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br Sigma g glycerol Chemworks Beijing China g propylene glyc
2020-08-03
(Sigma), 1.5 g glycerol (Chemworks, Beijing, China), 1.5 g propylene glycol (Xilong Chemical Co. Ltd., Guangxi, China), and sterile water were churned and heated to 60 °C. The water phase was added slowly into the oil phase and expanded to 10 mL with sterile water to form the colostrum. Then, the
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br Determination of TNF and VEGF br Tumor necrosis factor
2020-08-03
3.8. Determination of TNF-α and VEGF Tumor necrosis factor-alpha (TNF-α) is a multifunctional proinflam-matory cytokine that possesses a wide variety of biological activities in-cluding multiple chronic inflammatory and immunomodulatory properties [54,55]. Besides, it has been described as a p